Description

4-Chloro-2,6-Dimethoxy-5-Pyrimidinecarboxaldehyde-13C is a stable isotope-labeled (carbon-13) derivative of a key pyrimidine aldehyde intermediate. This compound is essential for advanced research and development, providing a critical building block for the synthesis of isotopically labeled pharmaceuticals and agrochemicals. It is primarily utilized by researchers and process chemists in pharmaceutical development, agrochemical research, and analytical chemistry for applications such as tracer studies, metabolic pathway analysis, and the synthesis of novel labeled compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of carbon-13 labeled active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer drug research.
• Metabolic Tracer: Used in pharmacokinetic and metabolic pathway studies to track the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Agrochemical Research: Serves as a precursor in the development of novel, isotopically labeled pesticides and herbicides for environmental fate studies.
• Analytical Reference Standard: Employed as an internal standard in quantitative mass spectrometry (LC-MS, GC-MS) for accurate bioanalysis and impurity profiling.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by enabling the synthesis of specifically labeled analogs for biological evaluation.
• Chemical Biology: Used in probe development for studying enzyme mechanisms and protein-ligand interactions using isotopic labeling techniques.

Basic Information

Product Name	4-Chloro-2,6-Dimethoxy-5-Pyrimidinecarboxaldehyde-13C
CAS No.	1391054-67-3
Molecular Formula	C7H7Cl13CN2O3
Molecular Weight	~203.59 g/mol (for 13C labeled form)
Synonyms	5-Formyl-4-chloro-2,6-dimethoxypyrimidine-13C; 4-Chloro-2,6-dimethoxy-5-pyrimidinecarbaldehyde-13C; 4-Chloro-2,6-dimethoxypyrimidine-5-carboxaldehyde-13C; 5-Pyrimidinecarboxaldehyde, 4-chloro-2,6-dimethoxy-, 13C-labeled; Carbon-13 Labeled 4-Chloro-2,6-dimethoxy-5-pyrimidinecarboxaldehyde; [13C]-4-Chloro-2,6-dimethoxy-5-pyrimidinecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,6-Dimethoxy-5-Pyrimidinecarboxaldehyde-13C is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment. Each batch is characterized by advanced analytical techniques including NMR (1H, 13C), HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing purity, isotopic enrichment (atom % 13C), and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C NMR)	≥ 99 atom % 13C
Chemical Purity (NMR)	≥ 97%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.