Description

1-Chloro-1-Deoxyglycerol-13C3 is a stable isotope-labeled analog of 1-chloro-1-deoxyglycerol, where three carbon atoms are replaced with the carbon-13 isotope. This compound serves as a critical internal standard and tracer in advanced analytical and metabolic research, ensuring unparalleled accuracy in quantitative mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in lipid metabolism, drug metabolism and pharmacokinetics (DMPK), and biomarker discovery studies.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Essential as an internal standard for the precise quantification of unlabeled 1-chloro-1-deoxyglycerol and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used as a stable isotope tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds and their intermediates.
• Lipidomics and Metabolic Pathway Analysis: Enables detailed tracing and flux analysis within glycerolipid and phospholipid biosynthesis pathways in cellular and in vivo models.
• Biomarker Research and Validation: Supports the development and validation of clinical assays for disease-specific metabolites by providing a reference point with distinct mass shift.
• Synthetic Chemistry Reference: Acts as a labeled building block or reference compound in the synthesis of more complex 13C-labeled molecules for research purposes.
• Quality Control in API Manufacturing: Can be employed in analytical method development and validation within GMP environments for monitoring process-related impurities.

Basic Information

Product Name	1-Chloro-1-Deoxyglycerol-13C3
CAS No.	1391053-60-3
Molecular Formula	C313C3H7ClO2 or C3H7ClO2 (13C3)
Molecular Weight	~141.5 g/mol (13C-labeled)
Synonyms	1-Chloro-1-deoxy-[13C3]glycerol; 1-Chloro-1-deoxy-sn-glycerol-13C3; 3-Chloro-1,2-propanediol-13C3; 3-Chloropropane-1,2-diol-13C3; α-Chlorohydrin-13C3; 3-MCPD-13C3; 1-Chloro-2,3-dihydroxypropane-13C3; Glycerol 1-chlorohydrin-13C3
EINECS	Contact for details

Quality Control

Every batch of 1-Chloro-1-Deoxyglycerol-13C3 is manufactured and analyzed under strict quality protocols to ensure isotopic purity, chemical purity, and batch-to-batch consistency critical for research integrity. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity, and identity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.