Description

5-[[(4S)-2-Oxo-4-Oxazolidinyl]Methyl]-1H-Indole-3-Acetic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized indole-oxazolidinone hybrid structure. This compound is critical for the research and development of novel therapeutic agents, particularly in the field of anti-inflammatory and central nervous system (CNS) drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex, biologically active molecules.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new chemical entities (NCEs) targeting specific biological pathways.
• Anti-inflammatory Drug Research: Used in the synthesis of potential non-steroidal anti-inflammatory drug (NSAID) candidates due to its indole-3-acetic acid ester moiety.
• CNS-Active Compound Development: Employed in creating analogs for neurological disorder research, leveraging the structural features of the oxazolidinone ring.
• Medicinal Chemistry & SAR Studies: Provides a versatile scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Chemistry & Scale-Up: Supplied to support route scouting, optimization, and pilot-scale production of target active pharmaceutical ingredients (APIs).
• Reference Standard: Used as an analytical standard for quality control and method development in regulatory submissions.

Basic Information

Product Name	5-[[(4S)-2-Oxo-4-Oxazolidinyl]Methyl]-1H-Indole-3-Acetic Acid Methyl Ester
CAS No.	1391052-71-3
Molecular Formula	C15H16N2O4
Molecular Weight	288.30 g/mol
Synonyms	Methyl 5-[(4S)-2-oxo-1,3-oxazolidin-4-yl]methyl-1H-indole-3-acetate; (4S)-4-[(3-Carbomethoxymethyl-1H-indol-5-yl)methyl]-2-oxazolidinone; 1H-Indole-3-acetic acid, 5-[[(4S)-2-oxo-4-oxazolidinyl]methyl]-, methyl ester; (S)-4-((3-(Methoxycarbonylmethyl)-1H-indol-5-yl)methyl)oxazolidin-2-one; Oxazolidinone-indole hybrid intermediate.
EINECS	Contact for details

Quality Control

Our production of 5-[[(4S)-2-Oxo-4-Oxazolidinyl]Methyl]-1H-Indole-3-Acetic Acid Methyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure compliance with research-grade and cGMP standards for advanced intermediates. A detailed Certificate of Analysis (COA) providing identity, purity (HPLC), chiral purity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.