Description

Sodium α-Keto-β-Methylvalerate-13C3 is a stable, isotopically labeled sodium salt of a key branched-chain α-keto acid, essential for advanced metabolic research and pharmaceutical development. This high-purity compound provides a critical internal standard for mass spectrometry, enabling precise quantification and pathway analysis in complex biological matrices. It is primarily utilized by researchers and manufacturers in the fields of stable isotope tracer studies, clinical diagnostics, and the synthesis of novel therapeutic agents.

Application

• Stable Isotope Tracer Studies: Used as a 13C-labeled precursor for investigating branched-chain amino acid (BCAA) metabolism, including leucine and isoleucine catabolic pathways in mammalian systems.
• Mass Spectrometry (MS) & LC-MS/MS: Serves as a critical internal standard for the accurate quantification of endogenous α-keto-β-methylvalerate and related metabolites in plasma, urine, and tissue samples.
• Clinical Diagnostics & Metabolomics: Enables research into metabolic disorders such as Maple Syrup Urine Disease (MSUD) and other inborn errors of metabolism.
• Pharmaceutical R&D: Employed in the synthesis and metabolic fate studies of drug candidates targeting metabolic enzymes or pathways involving BCAAs.
• Nutritional Science Research: Facilitates studies on protein metabolism, muscle physiology, and the metabolic effects of dietary interventions.
• Biochemical Reagent: Acts as a substrate for enzymatic assays involving branched-chain α-ketoacid dehydrogenase (BCKDH) complex.

Basic Information

Product Name	Sodium α-Keto-β-Methylvalerate-13C3
CAS No.	1391052-48-4
Molecular Formula	C6H913C3NaO3 *
Molecular Weight	~177.12 g/mol (for 13C3 labeled form) *
Synonyms	Sodium 2-Oxo-3-methylvalerate-13C3
2-Keto-3-methylvaleric acid-13C3 sodium salt
α-Keto-β-methylvalerate-13C3 sodium salt
KMV-13C3 sodium salt
Sodium 3-Methyl-2-oxopentanoate-13C3
2-Oxo-3-methylpentanoic acid-13C3 sodium salt
(Sodium) α-Ketoisocaproate-13C3 related isomer (common research context)
EINECS	Contact for details

* Formula and weight are based on the unlabeled compound structure and typical labeling position. Exact values depend on the specific 13C enrichment sites and level. Contact us for precise data.

Quality Control

Every batch of Sodium α-Keto-β-Methylvalerate-13C3 is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. We provide comprehensive Certificates of Analysis (COA) that detail specifications including assay by NMR/HPLC, isotopic purity (13C enrichment) by MS, and related substance profiles. Our quality systems support compliance with relevant guidelines for GMP manufacturing of non-radioactive labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC / Titration)	≥95% (Anhydrous basis)
Isotopic Purity (13C3)	≥98 atom % 13C (Typical)
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	Conforms
Specific Rotation (if applicable)	Contact for details
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.