Description

Teneligliptin D8 is a deuterium-labeled analog of the antidiabetic drug Teneligliptin, specifically identified by CAS NO 1391012-95-5. This stable isotope-labeled compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on diabetes research and drug development.

Application

• Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Teneligliptin in biological matrices.
• Essential for conducting pharmacokinetic (PK) and bioavailability studies during clinical trials for Teneligliptin and related dipeptidyl peptidase-4 (DPP-4) inhibitors.
• Facilitates drug metabolism and disposition (DMPK) research, aiding in the identification and quantification of metabolites.
• Supports forensic and anti-doping analysis where accurate measurement of Teneligliptin is required.
• Enables method development and validation in regulatory-compliant bioanalytical laboratories.
• Applied in academic research investigating the mechanisms of action and metabolic pathways of DPP-4 inhibitors.

Basic Information

Item	Detail
Product Name	Teneligliptin D8
CAS No.	1391012-95-5
Molecular Formula	C22H22D8N6O2S
Molecular Weight	426.60 g/mol
Synonyms	Teneligliptin-d8; (2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl-d8-(1,3-thiazolidin)-3-yl]methanone; BMS-477118-d8; BR-A-657-d8; GW-869233X-d8; Deuterated Teneligliptin; Teneligliptin Internal Standard
EINECS	Contact for details

Quality Control

Our Teneligliptin D8 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by comprehensive analytical data, including NMR and Mass Spectrometry reports to confirm deuteration level and identity. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuteration Degree)	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.