Description

tert-Butyl 5-(Aminomethyl)-1H-Indole-1-Carboxylate Hydrochloride is a high-purity, protected indole derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for research and development in medicinal chemistry, providing a versatile scaffold for the creation of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetic Synthesis: Serves as a building block for creating indole-based peptidomimetics and constrained peptides.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for target validation and biological pathway studies.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents and plant growth regulators.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in heterocyclic chemistry and synthetic methodology.

Basic Information

Product Name	tert-Butyl 5-(Aminomethyl)-1H-Indole-1-Carboxylate Hydrochloride
CAS No.	1390654-71-3
Molecular Formula	C15H21ClN2O2
Molecular Weight	296.79 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 5-(aminomethyl)-, 1,1-dimethylethyl ester, hydrochloride; 5-(Aminomethyl)-1H-indole-1-carboxylic acid tert-butyl ester hydrochloride; Boc-5-(aminomethyl)indole hydrochloride; tert-Butyl 5-(aminomethyl)indole-1-carboxylate HCl; 1-Boc-5-(aminomethyl)indole hydrochloride; 5-(Aminomethyl)indole-1-N-Boc hydrochloride; N-Boc-5-(aminomethyl)indole hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(Aminomethyl)-1H-Indole-1-Carboxylate Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.