Description

(1R)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid CAS NO 1389890-72-5 is a chiral, non-proteinogenic amino acid derivative belonging to the tetrahydroisoquinoline class, valued for its role as a sophisticated building block in advanced organic synthesis. Its significance lies in its rigid, bicyclic structure and functional groups, which are critical for constructing complex molecules with precise stereochemistry. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used as a building block for creating advanced, biologically active compounds in crop protection and pesticide development.
• Asymmetric Catalysis & Ligand Design: Serves as a precursor for chiral ligands and catalysts used in stereoselective chemical transformations.
• Peptidomimetics & Bioactive Molecule Design: Incorporated into peptide analogs and other bioactive scaffolds to modulate biological activity and stability.
• Academic & Industrial R&D: A valuable compound for methodological studies in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.

Basic Information

Product Name	(1R)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid
CAS No.	1389890-72-5
Molecular Formula	C10H11NO3
Molecular Weight	193.20 g/mol
Synonyms	(1R)-1,2,3,4-Tetrahydro-6-hydroxy-1-isoquinolinecarboxylic acid; (R)-6-Hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid; (1R)-6-Hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylic acid; (R)-THIQ-1-COOH-6-OH; 6-Hydroxy-(R)-Tic-OH; (R)-1-Carboxy-6-hydroxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Every batch of (1R)-6-Hydroxy-1,2,3,4-Tetrahydroisoquinoline-1-Carboxylic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and cGMP-grade production. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept under an inert atmosphere for long-term storage to maintain optimal quality. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.