Description

3-Isoquinolinemethanol, 6-Fluoro-1,2,3,4-Tetrahydro-, (3S)- is a chiral, fluorinated tetrahydroisoquinoline derivative, a sophisticated building block of significant interest in modern synthetic chemistry. Its value lies in the precise stereochemistry and the presence of the fluorine atom, which are critical for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical research and development organizations engaged in the discovery of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncological targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and stereochemistry on potency and selectivity.
• API Development: A potential precursor in the synthesis of fluorinated tetrahydroisoquinoline-based active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in enantioselective catalytic processes to construct complex molecular architectures.
• Chemical Biology Probes: Utilized in the development of labeled compounds or probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines where required.

Basic Information

Item	Details
Product Name	3-Isoquinolinemethanol, 6-Fluoro-1,2,3,4-Tetrahydro-, (3S)-
CAS No.	1389391-15-4
Molecular Formula	C₁₀H₁₂FNO
Molecular Weight	181.21 g/mol
Synonyms	(3S)-6-Fluoro-1,2,3,4-tetrahydro-3-isoquinolinemethanol; (S)-6-Fluoro-1,2,3,4-tetrahydroisoquinoline-3-methanol; 6-Fluoro-(3S)-1,2,3,4-tetrahydro-3-isoquinolinemethanol; (3S)-6-Fluoro-1,2,3,4-tetrahydroisoquinoline-3-carbinol; (S)-6-Fluoro-1,2,3,4-tetrahydro-3-isoquinolinecarbinol; 6-Fluoro-(S)-1,2,3,4-tetrahydro-3-isoquinolinemethanol; (3S)-6-Fluoro-1,2,3,4-tetrahydroisoquinolin-3-ylmethanol
EINECS	Contact for details

Quality Control

Every batch of (3S)-6-Fluoro-1,2,3,4-tetrahydro-3-isoquinolinemethanol is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from advanced techniques including HPLC, GC, NMR, and chiral analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.