Description

(R)-5-(Methylsulfonyl)Isoindoline-1-Carboxylic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound matters for its role in the synthesis of complex, biologically active molecules, particularly in the development of new therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Drug Discovery: Used in medicinal chemistry for the synthesis of compound libraries and lead optimization candidates.
• Asymmetric Synthesis: Serves as a valuable starting material or intermediate in stereoselective synthesis routes.
• Proteolysis Targeting Chimera (PROTAC) Development: Potential use as a component in the linker or warhead design of targeted protein degraders.
• Chemical Biology Research: Employed in the study of enzyme function and receptor-ligand interactions.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for clinical trial material and commercial API manufacturing.

Basic Information

Product Name	(R)-5-(Methylsulfonyl)Isoindoline-1-Carboxylic Acid
CAS No.	1389390-05-9
Molecular Formula	C11H11NO4S
Molecular Weight	253.27 g/mol
Synonyms	(R)-5-(Methanesulfonyl)isoindoline-1-carboxylic acid; (R)-1-Carboxy-5-(methylsulfonyl)isoindoline; (R)-5-Methylsulfonyl-1-isoindolinecarboxylic Acid; 1-Isoindolinecarboxylic acid, 5-(methylsulfonyl)-, (R)-; (R)-5-Methanesulfonylisoindoline-1-carboxylic Acid; (R)-5-(Methylsulfonyl)-2,3-dihydro-1H-isoindole-1-carboxylic Acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity of ≥97% (HPLC) and can supply higher grades, including ≥98% and ≥99%, to meet specific project requirements. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality system supports development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.