Description

(R)-5-(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)-4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidine CAS NO 1388894-05-0 is a high-purity, advanced pharmaceutical intermediate featuring a complex, functionalized heterocyclic structure. This compound is a critical chiral building block for the synthesis of targeted kinase inhibitors and other biologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and inflammatory disease pathways.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potent kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile functional groups.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition mechanisms and cellular signaling pathways.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects.

Basic Information

Product Name	(R)-5-(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)-4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidine
CAS No.	1388894-05-0
Molecular Formula	C18H27ClN2O1S1Si1
Molecular Weight	382.02 g/mol
Synonyms	(R)-4-Chloro-5-[2-[(tert-butyldimethylsilyl)oxy]ethyl]-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine; (R)-5-(2-((tert-Butyldimethylsilyl)oxy)ethyl)-4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine; TBS-protected thienopyrimidine intermediate; CAS 1388894-05-0; Cyclopentathienopyrimidine derivative; Chiral TBS ether intermediate; Kinase inhibitor intermediate CP-724714 related compound.
EINECS	Contact for details

Quality Control

Our (R)-5-(2-((tert-Butyldimethylsilyl)Oxy)Ethyl)-4-Chloro-6,7-Dihydro-5H-Cyclopenta[4,5]Thieno[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure high chemical and isomeric purity suitable for advanced research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to maintain stability and purity. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.