Description

(R)-(5-Bromo-1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanol is a high-purity chiral building block of significant importance in modern synthetic organic chemistry. This compound matters as a key intermediate for the development of novel pharmaceuticals, particularly in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular disorders. Pharmaceutical research organizations and fine chemical manufacturers need it for constructing complex molecular architectures with precise stereochemistry, enabling the creation of more potent and selective drug candidates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and cardiovascular therapeutics.
• Asymmetric Synthesis: Used as a building block in catalytic asymmetric reactions to introduce the tetrahydroisoquinoline scaffold with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore novel bioactive molecules.
• Chemical Biology Probes: Serves as a precursor for developing molecular probes to study enzyme function and receptor interactions.
• Process Chemistry Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the custom synthesis of proprietary compounds for clients in the life sciences sector.

Basic Information

Product Name	(R)-(5-Bromo-1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanol
CAS No.	1388838-68-3
Molecular Formula	C10H12BrNO
Molecular Weight	242.11 g/mol
Synonyms	(3R)-5-Bromo-1,2,3,4-tetrahydro-3-isoquinolinemethanol; (R)-5-Bromo-1,2,3,4-tetrahydroisoquinoline-3-methanol; (R)-5-Bromo-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline; (R)-3-(Hydroxymethyl)-5-bromo-1,2,3,4-tetrahydroisoquinoline; 5-Bromo-(R)-TIC-methanol; (R)-TIC(Br)-CH2OH
EINECS	Contact for details

Quality Control

Our (R)-(5-Bromo-1,2,3,4-Tetrahydroisoquinolin-3-Yl)Methanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.