Description

(R)-2,3-Dihydro-1H-Isoindole-1-Carboxylic Acid CAS NO 1388796-96-0 is a chiral isoindoline derivative, a high-value building block in modern organic synthesis. Its primary importance lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals requiring precise three-dimensional architecture.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel drug candidates, especially in central nervous system (CNS) and cardiovascular therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced, stereoselective pesticides and herbicides where the specific (R)-enantiomer confers desired biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Peptidomimetics & Bioactive Molecule Construction: Incorporated into the backbone of peptidomimetic compounds and other bioactive molecules to modulate their pharmacokinetic properties and receptor binding affinity.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and for exploring new chemical spaces in medicinal chemistry programs.

Basic Information

Product Name	(R)-2,3-Dihydro-1H-Isoindole-1-Carboxylic Acid
CAS No.	1388796-96-0
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	(R)-Isoindoline-1-carboxylic acid; (R)-1,3-Dihydro-2H-isoindole-1-carboxylic acid; (R)-1-Carboxyisoindoline; (R)-2,3-Dihydro-1H-isoindole-1-carboxylic acid; (R)-1,2,3,4-Tetrahydroisoquinoline-1-carboxylic acid (related structure); (R)-1-Azabicyclo[4.3.0]nonane-1-carboxylic acid derivative; (R)-PCAI; (R)-PHTH
EINECS	Contact for details

Quality Control

Our (R)-2,3-Dihydro-1H-Isoindole-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric purity and identity confirmation via spectroscopic methods. We provide Certificates of Analysis (COA) with each shipment, detailing purity, chiral excess, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.