Description

(R)-4-Ethynyloxazolidin-2-One CAS NO 1388663-99-7 is a high-value, chiral oxazolidinone derivative featuring a terminal alkyne functional group. This compound serves as a critical chiral auxiliary and building block in asymmetric synthesis, enabling the stereoselective construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of potential drug candidates, particularly in medicinal chemistry research.
• Chiral Auxiliary: Used to control stereochemistry in organic reactions such as aldol, alkylation, and Diels-Alder reactions.
• Chemical Biology Probe Synthesis: The ethynyl group allows for efficient conjugation via click chemistry (CuAAC) for labeling proteins or other biomolecules.
• Material Science Research: Acts as a monomer or precursor for constructing chiral polymers or advanced organic frameworks with specific optical properties.
• Catalyst Ligand Development: Serves as a precursor for synthesizing novel chiral ligands used in homogeneous catalysis.
• Academic & Process R&D: Employed in university and industrial laboratories for method development and scale-up studies in asymmetric synthesis.

Basic Information

Product Name	(R)-4-Ethynyloxazolidin-2-One
CAS No.	1388663-99-7
Molecular Formula	C5H5NO2
Molecular Weight	111.10 g/mol
Synonyms	(R)-4-Ethynyl-2-oxazolidinone; (4R)-4-Ethynyl-1,3-oxazolidin-2-one; (R)-(-)-4-Ethynyl-2-oxazolidinone; 4-Ethynyl-2-oxazolidinone, (R)-; Oxazolidin-2-one, 4-ethynyl-, (4R)-; Evans Chiral Auxiliary Derivative; Chiral Oxazolidinone Alkyne
EINECS	Contact for details

Quality Control

Our (R)-4-Ethynyloxazolidin-2-One is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.