Description

3-Chloro-4-(Trifluoromethyl)-1H-Indazole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a halogenated indazole scaffold with a trifluoromethyl group, offering unique electronic and steric properties for modulating the bioactivity and physicochemical profile of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of small molecule drug candidates, particularly in oncology, CNS disorders, and inflammation.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the stability and lipophilicity imparted by the CF3 group.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials and functional polymers.
• Chemical Biology Probe: Utilized in medicinal chemistry to explore structure-activity relationships (SAR) and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects and library production.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethyl)-1H-Indazole
CAS No.	1388070-12-9
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	3-Chloro-4-(trifluoromethyl)-1H-indazole; 4-(Trifluoromethyl)-3-chloro-1H-indazole; 1H-Indazole, 3-chloro-4-(trifluoromethyl)-; 3-Chloro-4-trifluoromethylindazole; 1388070-12-9; 3-Chloro-4-(trifluoromethyl)indazole
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethyl)-1H-Indazole is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed specifications for all key parameters, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.