Description

4-(Fluorosulfonyl)Thiophene-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block featuring both a fluorosulfonyl group and a carboxylic acid moiety on a thiophene core. This unique bifunctional structure makes it a critical intermediate for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), enabling the introduction of key functional handles for further derivatization. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging its reactive sites for creating diverse bioactive compounds.
• Polymer & Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers, conductive materials, and liquid crystals with tailored electronic properties.
• Chemical Research & Development: A versatile reagent for organic synthesis, enabling Suzuki-Miyaura coupling, amide bond formation, and other cross-coupling reactions via its carboxylic acid group.
• Ligand & Catalyst Design: Useful for constructing complex chelating ligands in coordination chemistry and catalysis due to its sulfur and oxygen donor atoms.

Basic Information

Product Name	4-(Fluorosulfonyl)Thiophene-2-Carboxylic Acid
CAS No.	1384428-37-8
Molecular Formula	C5H3FO4S2
Molecular Weight	210.20 g/mol
Synonyms	2-Thiophenecarboxylic acid, 4-(fluorosulfonyl)-; 4-Fluorosulfonylthiophene-2-carboxylic acid; 2-Carboxy-4-fluorosulfonylthiophene; 4-(Fluorosulphonyl)thiophene-2-carboxylic acid; Thiophene-2-carboxylic acid, 4-(fluorosulfonyl)- (9CI)
EINECS	Contact for details

Quality Control

Our 4-(Fluorosulfonyl)Thiophene-2-Carboxylic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production standards. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.