Description

(S)-Indacaterol CAS NO 1384188-70-8 is a high-purity enantiomer of the long-acting beta2-adrenergic receptor agonist (LABA) indacaterol. This compound is a critical pharmaceutical intermediate and reference standard in the development and quality control of respiratory medications. It is primarily required by pharmaceutical R&D laboratories, analytical service providers, and manufacturers of active pharmaceutical ingredients (APIs). The material is essential for ensuring the efficacy and safety profile of final drug products targeting chronic obstructive pulmonary disease (COPD) and asthma.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, LC-MS, and NMR for the identification and quantification of indacaterol in drug substances and products.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key chiral building block in the synthesis of the (S)-enantiomer of indacaterol maleate, the therapeutically active form.
• Analytical Method Development & Validation: Critical for developing and validating stereospecific analytical methods to control enantiomeric purity.
• Pharmacology and Preclinical Research: Employed in in-vitro and in-vivo studies to investigate the specific pharmacological activity, metabolism, and toxicity profile of the (S)-enantiomer.
• Impurity Profiling: Used to identify, characterize, and quantify isomeric and process-related impurities in indacaterol API batches.
• Regulatory Submissions: Provides essential data and characterization for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).

Basic Information

Product Name	(S)-Indacaterol
CAS No.	1384188-70-8
Molecular Formula	C24H28N2O3
Molecular Weight	392.49 g/mol
Synonyms	(S)-5-[(R)-2-(5,6-Diethyl-2,3-dihydro-1H-inden-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one; (S)-Indacaterol; (S)-QAB149; UNII-4V5L3NQ45E; Indacaterol S-enantiomer; (S)-Indacaterol free base
EINECS	Contact for details

Quality Control

Our (S)-Indacaterol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and strength. We support compliance with ICH Q7 guidelines and can supply material suitable for use under GMP conditions for non-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.