Description

[2H9]-Cabazitaxel is a deuterated isotopologue of the established chemotherapeutic agent cabazitaxel, where nine hydrogen atoms are replaced by the stable isotope deuterium. This strategic modification is designed to enhance metabolic stability and improve pharmacokinetic profiles, making it a critical tool for advanced drug metabolism and pharmacokinetics (DMPK) studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in the development and validation of novel oncology therapeutics.

Application

• Internal Standard for Bioanalytical Assays: Serves as a critical reference compound in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of cabazitaxel in biological matrices like plasma and tissue.
• Drug Metabolism Studies (DMPK): Used to investigate the metabolic pathways, stability, and pharmacokinetic behavior of cabazitaxel, aiding in the design of improved drug candidates.
• Mass Spectrometry Method Development: Essential for developing and validating sensitive and specific analytical methods due to its near-identical chemical properties with distinct mass.
• Clinical Research & Pharmacokinetics: Enables accurate tracking of drug concentration over time in clinical trial samples to establish dosing regimens.
• Isotope Dilution Analysis: Employed in high-precision quantitative analysis to correct for analyte loss during sample preparation.
• Mechanistic Toxicology Studies: Facilitates the differentiation between administered drug and its metabolites in studies investigating drug-induced toxicity.

Basic Information

Product Name	[2H9]-Cabazitaxel
CAS No.	1383572-19-7
Molecular Formula	C45H58D9NO14
Molecular Weight	~ 848.0 g/mol
Synonyms	Cabazitaxel-d9; Deuterated Cabazitaxel; Jevtana-d9; XRP6258-d9; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl (2R)-2-hydroxy-3-[(2H3)methyl](2H6)butanoate
EINECS	Contact for details

Quality Control

Our [2H9]-Cabazitaxel is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive analytical applications. Each batch undergoes comprehensive analysis, including HPLC for chemical purity and MS for isotopic purity and enrichment. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Isotopic Enrichment	≥ 99% at labeled positions
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.