Description

2-(2-((2,6-Dichloro-4-Methoxyphenyl)Amino)Phenyl-D4)-N,n-Dimethylacetamide is a deuterated analog of a key pharmaceutical intermediate, offering enhanced metabolic stability and traceability for advanced research and development. This high-purity compound is critical for conducting mass spectrometry studies, pharmacokinetic (PK) profiling, and serving as an internal standard in quantitative bioanalytical assays. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on innovating and validating new therapeutic agents.

Application

• Internal Standard for LC-MS/MS: Essential for accurate quantification in bioanalytical method development and validation due to its isotopic purity.
• Metabolite Identification & PK/PD Studies: Used as a tracer to study the absorption, distribution, metabolism, and excretion (ADME) of the parent drug candidate.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products.
• Deuterated Reference Material: Serves as a certified reference standard for quality control in active pharmaceutical ingredient (API) manufacturing.
• Drug Discovery Research: Employed in mechanistic studies to understand drug-receptor interactions without interference from metabolic processes.
• Regulatory Submission Support: Provides critical data for regulatory filings (e.g., with FDA, EMA) requiring validated analytical methods with stable isotope-labeled standards.

Basic Information

Product Name	2-(2-((2,6-Dichloro-4-Methoxyphenyl)Amino)Phenyl-D4)-N,n-Dimethylacetamide
CAS No.	1382084-37-8
Molecular Formula	C17H14D4Cl2N2O2
Molecular Weight	357.26 g/mol (for deuterated form)
Synonyms	N,N-Dimethyl-2-[2-[(2,6-dichloro-4-methoxyphenyl)amino]phenyl-d4]acetamide; Deuterated Diclofenac Metabolite Standard (D4-labeled); 2-(2-((2,6-Dichloro-4-Methoxyphenyl)Amino)Phenyl-d4)acetdimethylamide; [D4]-2-(2-((2,6-Dichloro-4-Methoxyphenyl)Amino)Phenyl)-N,N-dimethylacetamide; D4-Labeled Diclofenac Amide Analog; (2,6-Dichloro-4-methoxyphenyl)-[2-(2-dimethylamino-2-oxoethyl)phenyl-d4]amine; Stable Isotope-Labeled Pharmaceutical Intermediate; CAS 1382084-37-8
EINECS	Contact for details

Quality Control

Every batch of our deuterated compounds is manufactured under strict quality management systems to ensure isotopic and chemical purity. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as isotopic enrichment (D-content), chemical purity by HPLC, and identification by NMR and MS. Our quality protocols are designed to meet the stringent requirements of GMP/GLP-compliant laboratories and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.