Description

5-Bromo-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-value, multi-halogenated indazole derivative protected by a tetrahydropyran (THP) group. This compound serves as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis, enabling the construction of complex molecular architectures. It is primarily utilized by research and development teams in the pharmaceutical, agrochemical, and material science industries for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Agrochemical Research: Used as a building block for developing new active ingredients with potential herbicidal or pesticidal properties.
• Material Science: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Chemical Biology: Employed in the creation of molecular probes and tool compounds for studying biological pathways and target engagement.
• Cross-Coupling Reactions: The bromo and iodo substituents make it an excellent substrate for palladium-catalyzed Suzuki, Sonogashira, and Buchwald-Hartwig reactions.
• Library Synthesis: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry.

Basic Information

Product Name	5-Bromo-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1380917-35-0
Molecular Formula	C₁₂H₁₂BrIN₂O
Molecular Weight	407.05 g/mol
Synonyms	1-(Oxan-2-yl)-5-bromo-3-iodo-1H-indazole; 5-Bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole; 1H-Indazole, 5-bromo-3-iodo-1-(tetrahydro-2H-pyran-2-yl)-; 5-Br-3-I-1-THP-indazole; THP-protected 5-bromo-3-iodoindazole
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Iodo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.