Description

L-Serine-2,3,3-D3-n-Fmoc is a deuterium-labeled, Fmoc-protected derivative of the amino acid L-serine, specifically designed for advanced research and development. This compound is essential for applications requiring isotopic labeling, such as metabolic pathway tracing and mass spectrometry-based proteomics, where it provides critical data integrity and sensitivity. It is primarily utilized by pharmaceutical researchers, analytical chemists, and biotech companies engaged in peptide synthesis, drug discovery, and biomarker analysis.

Application

• Isotopic Internal Standards: Used as a quantitative reference standard in LC-MS/MS and GC-MS for the accurate measurement of L-serine and related metabolites in complex biological matrices.
• Peptide Synthesis & Medicinal Chemistry: Serves as a deuterium-labeled building block in solid-phase and solution-phase peptide synthesis for creating isotopically labeled peptides for pharmacokinetic and metabolic stability studies.
• Metabolic Flux Analysis (MFA): Employed in tracer studies to investigate central carbon metabolism, glycine/serine metabolism, and one-carbon unit pathways in cell cultures and model organisms.
• Proteomics Research: Facilitates the development of stable isotope labeling by amino acids in cell culture (SILAC) and other mass-tagging strategies for quantitative proteomics.
• Biomarker Discovery & Validation: Acts as a crucial tool in the development and validation of clinical assays for disease-related metabolites.
• NMR Spectroscopy: Provides a non-radioactive, stable isotopic label for structural and dynamic studies of proteins and peptides using nuclear magnetic resonance.

Basic Information

Product Name	L-Serine-2,3,3-D3-n-Fmoc
CAS No.	1380308-48-4
Molecular Formula	C18H14D3NO5
Molecular Weight	328.35 g/mol
Synonyms	Fmoc-Ser(D3)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-hydroxy-2,3,3-trideuteriopropanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-serine-2,3,3-d3; Fmoc-L-serine-d3; Nα-Fmoc-L-serine-2,3,3-d3; Deuterated Fmoc-L-serine; Fmoc-Ser(d3)-OH; L-Serine-2,3,3-d3, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Every batch of L-Serine-2,3,3-D3-n-Fmoc is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards for research use. Our quality commitment includes comprehensive analysis via HPLC, NMR, and Mass Spectrometry to verify chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results for assay, chiral purity, deuterium enrichment, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.