Description

Exo Bcn-o-Pnb CAS NO 1380006-72-3 is a specialized organic compound belonging to the class of functionalized bicyclo[6.1.0]nonynes (BCN), widely recognized as a versatile bioorthogonal reagent. This high-purity chemical building block is critical for advanced research and development in life sciences, enabling precise and efficient conjugation under mild, physiological conditions. It is an essential tool for pharmaceutical researchers, bioconjugation specialists, and material scientists working on drug delivery systems, diagnostic probes, and novel biomaterials.

Application

• Bioorthogonal Labeling and Conjugation: Serves as a key reagent for strain-promoted azide-alkyne cycloaddition (SPAAC) reactions to label biomolecules like proteins, antibodies, and oligonucleotides.
• Chemical Biology & Proteomics: Used for site-specific modification of proteins and cell surface engineering to study biological processes and protein function.
• Pharmaceutical Development: Enables the creation of antibody-drug conjugates (ADCs) and other targeted therapeutic agents through controlled linker chemistry.
• Diagnostic Reagent Synthesis: A precursor for developing fluorescent probes, imaging agents, and contrast agents for in vitro and in vivo diagnostics.
• Polymer & Material Science: Functionalizes polymers, nanoparticles, and surfaces to create smart materials with specific biological recognition properties.
• Academic & Industrial R&D: A fundamental research chemical for exploring new bioorthogonal reactions and developing novel bioconjugation methodologies.

Basic Information

Product Name	Exo Bcn-o-Pnb
CAS No.	1380006-72-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	exo-BCN-O-PNB; exo-BCN-o-PNB Ester; (1S,8S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (4-nitrophenyl) carbonate; exo-BCN-PNB Carbonate; BCN(ONp); BCN-PNB; BCN active ester; BCN p-nitrophenyl carbonate
EINECS	Contact for details

Quality Control

Our Exo Bcn-o-Pnb is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support research and development requiring reliable and well-characterized bioorthogonal reagents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures (typically -20°C or as specified on the label). Keep the container sealed under an inert atmosphere if the material is moisture-sensitive. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.