Description

Thiol-Peg2-Acid CAS NO 1379649-73-6 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal thiol (-SH) group for conjugation and a carboxylic acid (-COOH) group for further functionalization. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific modification of peptides, proteins, and other biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, advanced drug delivery systems, and diagnostic probe development.

Application

• Bioconjugation Linker: Used to covalently attach drugs, dyes, or other functional molecules to proteins, antibodies, or peptides via the thiol and carboxylic acid groups.
• PEGylation Reagent: Serves as a key intermediate for creating PEGylated therapeutics, where the PEG chain improves solubility, stability, and pharmacokinetics.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or biosensor surfaces to create reactive sites for biomolecule immobilization.
• Crosslinking Agent: Facilitates the formation of hydrogels or polymer networks through reactions between the thiol and other functional groups.
• ADC (Antibody-Drug Conjugate) Development: Acts as a versatile spacer/linker in the synthesis of next-generation ADCs, connecting cytotoxic payloads to targeting antibodies.
• Diagnostic Reagent Synthesis: Used in the production of contrast agents and fluorescent probes for imaging and diagnostic applications.

Basic Information

Product Name	Thiol-Peg2-Acid
CAS No.	1379649-73-6
Molecular Formula	C9H18O5S
Molecular Weight	238.30 g/mol
Synonyms	2-[2-(2-Mercaptoethoxy)ethoxy]acetic acid; HS-PEG2-COOH; 3,6-Dioxa-8-mercaptooctanoic acid; Thiol-PEG2-acetic acid; α-Thio-ω-carboxy triethylene glycol; 8-Mercapto-3,6-dioxaoctanoic acid; SH-PEG2-COOH; PEG2 dithiol propionic acid (related compound)
EINECS	Contact for details

Quality Control

Our Thiol-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation of the thiol group. For long-term storage, desiccate to minimize moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Assay (Titration)	95.0 - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.