Description

tert-Butyl n-[(1S,2S)-Rel-2-(5-Bromothiophen-2-Yl)Cyclopropyl]Carbamate is a high-purity chiral building block featuring a bromothiophene moiety and a cyclopropylamine protected with a Boc group. This compound is specifically designed for advanced pharmaceutical research and development, offering a critical intermediate for constructing complex molecules with defined stereochemistry. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its versatile bromothiophene handle for cross-coupling reactions.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scalable synthesis of active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Employed in the discovery of new pesticides and herbicides, leveraging the biological activity often associated with thiophene derivatives.
• Chemical Biology: Useful as a probe or linker in the development of chemical tools for studying biological systems and target validation.
• Custom Synthesis: A foundational block for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis services.

Basic Information

Product Name	tert-Butyl n-[(1S,2S)-Rel-2-(5-Bromothiophen-2-Yl)Cyclopropyl]Carbamate
CAS No.	1379466-13-3
Molecular Formula	C12H16BrNO2S
Molecular Weight	318.23 g/mol
Synonyms	Boc-2-(5-Bromothiophen-2-yl)cyclopropylamine (rel-(1S,2S)-Isomer); (1S,2S)-rel-2-(5-Bromo-2-thienyl)cyclopropanamine 1,1-Dimethylethyl Carbamate; tert-Butyl ((1S,2S)-rel-2-(5-Bromothiophen-2-yl)cyclopropyl)carbamate; 2-(5-Bromothiophen-2-yl)cyclopropanamine N-Boc Protected; N-Boc-2-(5-bromothiophen-2-yl)cyclopropanamine; (rel-(1S,2S))-tert-Butyl (2-(5-bromothiophen-2-yl)cyclopropyl)carbamate; 1379466-13-3
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(1S,2S)-Rel-2-(5-Bromothiophen-2-Yl)Cyclopropyl]Carbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >97% by HPLC), chiral purity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.