Description

(4S,4'S)-2,2'-(Cyclopentane-1,1-Diyl)-Bis(4-Isopropyl-4,5-Dihydrooxazole) CAS NO 1379452-52-4 is a high-purity, chiral bis(oxazoline) ligand, a critical class of organocatalysts and auxiliaries in asymmetric synthesis. Its value lies in enabling precise stereochemical control for the production of enantiomerically pure pharmaceuticals and fine chemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient routes to chiral intermediates.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Cu, Pd, Zn) in enantioselective reactions like cyclopropanations, Diels-Alder reactions, and conjugate additions.
• Pharmaceutical Intermediate Synthesis: For the stereocontrolled construction of complex chiral molecules in active pharmaceutical ingredient (API) development.
• Agrochemical Research: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: As a building block for chiral polymers or frameworks with potential optical or sensory properties.
• Academic & Industrial R&D: A versatile tool for methodology development in organic and medicinal chemistry laboratories.
• Process Chemistry Optimization: Scaling up asymmetric transformations from laboratory to pilot plant and manufacturing scales.

Basic Information

Product Name	(4S,4'S)-2,2'-(Cyclopentane-1,1-Diyl)-Bis(4-Isopropyl-4,5-Dihydrooxazole)
CAS No.	1379452-52-4
Molecular Formula	C17H28N2O2
Molecular Weight	292.42 g/mol
Synonyms	(4S,4'S)-1,1'-Cyclopentanediylbis[4,5-dihydro-4-(1-methylethyl)-2-oxazole]; (S,S)-1,1'-Cyclopentanediylbis[4,5-dihydro-4-(1-methylethyl)-2-oxazole]; (S,S)-Cyclopentane-bis(4-isopropyl-4,5-dihydrooxazole); (S,S)-Cyclopentane-bis(4-isopropyl-2-oxazoline); (S,S)-Cyclopentyl-Box Ligand; (S,S)-Cp-Box; Chiral Bis(oxazoline) Ligand; BOX Ligand Derivative
EINECS	Contact for details

Quality Control

Our (4S,4'S)-2,2'-(Cyclopentane-1,1-Diyl)-Bis(4-Isopropyl-4,5-Dihydrooxazole) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.