Description

Crth2 Antagonist 1 is a potent and selective small-molecule inhibitor of the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). This compound is a critical research tool and pharmaceutical intermediate for developing novel anti-inflammatory and immunomodulatory therapies. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions focused on allergic diseases, asthma, and other inflammatory conditions.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery and development of novel CRTH2 antagonist drugs.
• In Vitro & In Vivo Studies: Used extensively in biochemical and cellular assays to study the role of the CRTH2 receptor pathway in allergic inflammation and immune response modulation.
• Mechanism of Action (MoA) Investigation: A vital tool for elucidating the pharmacological profile and signaling mechanisms of CRTH2 receptor antagonism.
• Preclinical Development: Employed in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and toxicology assessments for candidate drug molecules.
• High-Throughput Screening (HTS): Used as a control compound in screening campaigns to identify new chemical entities with CRTH2 inhibitory activity.
• Chemical Biology: Acts as a probe molecule to explore protein-ligand interactions and validate CRTH2 as a therapeutic target.

Basic Information

Product Name	Crth2 Antagonist 1
CAS No.	1379445-54-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CRTH2 Antagonist 1; 1379445-54-1; CRTH2 Inhibitor; Prostaglandin D2 Receptor 2 Antagonist; DP2 Receptor Antagonist; PGD2 Receptor CRTH2 Antagonist; (2-{[(2,4-Dichlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-yl)acetic acid (common structural core name); GSK- identifier series (potential); Research Compound for Allergic Inflammation.
EINECS	Contact for details

Quality Control

Our Crth2 Antagonist 1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.