Description

Methyl 5-Amino-4-Bromothiophene-2-Carboxylate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its reactive amino and bromo substituents on the thiophene ring, enabling precise derivatization for creating complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used to construct advanced fungicides, herbicides, and insecticides, leveraging the thiophene scaffold for enhanced bioactivity and environmental profile.
• Organic Electronic Materials: Serves as a building block for π-conjugated systems in the development of organic semiconductors, OLEDs (Organic Light-Emitting Diodes), and photovoltaic materials.
• Ligand and Catalyst Development: The amino group allows for functionalization to create novel ligands for transition metal catalysis and organocatalysts.
• Dye and Pigment Chemistry: Acts as an intermediate for synthesizing specialized dyes, pigments, and fluorescent markers with specific optical properties.
• Polymer and Resin Modification: Incorporated into polymer backbones to impart specific chemical resistance, thermal stability, or electronic properties to advanced engineering plastics.

Basic Information

Product Name	Methyl 5-Amino-4-Bromothiophene-2-Carboxylate
CAS No.	1379347-49-5
Molecular Formula	C6H6BrNO2S
Molecular Weight	236.09 g/mol
Synonyms	Methyl 5-amino-4-bromo-2-thiophenecarboxylate; 4-Bromo-5-aminothiophene-2-carboxylic acid methyl ester; 5-Amino-4-bromothiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-amino-4-bromo-, methyl ester; Methyl 4-bromo-5-aminothiophene-2-carboxylate; 4-Bromo-5-aminothiophene-2-methyl carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 5-Amino-4-Bromothiophene-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.