Description

4-Chlorobenzo[B]Thiophene-2-Carbonitrile is a high-purity, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmaceuticals and agrochemicals, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the benzothiophene core.
• Material Science Precursor: Acts as a building block for organic electronic materials, such as organic semiconductors and non-linear optical (NLO) materials.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce functionalized benzothiophene units.
• Dye & Pigment Industry: Utilized as an intermediate for synthesizing specialized dyes and pigments with unique chromophoric properties.
• Academic & Contract Research: A valuable reagent for methodological studies and discovery chemistry in university and CRO laboratories.

Basic Information

Product Name	4-Chlorobenzo[B]Thiophene-2-Carbonitrile
CAS No.	1378942-33-6
Molecular Formula	C9H4ClNS
Molecular Weight	193.65 g/mol
Synonyms	4-Chlorobenzo[b]thiophene-2-carbonitrile; 4-Chloro-1-benzothiophene-2-carbonitrile; 4-Chloro-2-cyanobenzo[b]thiophene; 2-Cyano-4-chlorobenzo[b]thiophene; 4-Chlorobenzo[b]thien-2-yl cyanide; 4-Chloro-benzo[b]thiophene-2-carbonitrile; Benzo[b]thiophene-2-carbonitrile, 4-chloro-
EINECS	Contact for details

Quality Control

Our 4-Chlorobenzo[B]Thiophene-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.