Description

1-(6-(Aminooxy)Hexyl)-1H-Pyrrole-2,5-Dione Hydrochloride is a high-purity chemical building block featuring a maleimide group and an aminooxy linker. This compound is specifically engineered for site-specific bioconjugation and click chemistry applications, enabling the stable and efficient labeling of biomolecules. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced materials science.

Application

• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Used to create stable, cleavable linkers for targeted cancer therapies.
• Protein and Peptide Labeling: Enables site-specific conjugation of fluorophores, drugs, or other payloads to cysteine residues via the maleimide group.
• Surface Functionalization for Biosensors: Immobilizes biomolecules onto chips or nanoparticles for diagnostic and research applications.
• Polymer Modification: Serves as a functional monomer or cross-linker for creating smart polymers and hydrogels with reactive handles.
• Oligonucleotide Conjugation: Facilitates the attachment of various moieties to nucleic acids for therapeutic and diagnostic probes.
• Chemical Biology Tool Development: A key reagent for constructing probes to study protein function and interactions in live cells.

Basic Information

Product Name	1-(6-(Aminooxy)Hexyl)-1H-Pyrrole-2,5-Dione Hydrochloride
CAS No.	1378306-38-7
Molecular Formula	C14H21N3O4 • HCl
Molecular Weight	323.80 g/mol (Free base: 287.33 g/mol)
Synonyms	6-Maleimidohexyloxyamine hydrochloride; Maleimide-PEG6-amine hydrochloride; 6-((Maleimido)hexyloxy)amine HCl; 1H-Pyrrole-2,5-dione, 1-[6-(aminooxy)hexyl]-, hydrochloride; Aminooxy-PEG6-maleimide HCl; N-(6-Aminooxyhexyl)maleimide hydrochloride; AMS-PEG6-NHS Ester precursor (reduced form)
EINECS	Contact for details

Quality Control

Our production of 1-(6-(Aminooxy)Hexyl)-1H-Pyrrole-2,5-Dione Hydrochloride adheres to stringent quality protocols suitable for research and pharmaceutical applications. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and other critical parameters are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.