Description

1-Cyclopentyl-5-Fluorobenzimidazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzimidazole core functionalized with a cyclopentyl and a fluorine substituent. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, including potential kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Serves as a core scaffold for the development and optimization of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Agrochemical Development: Used in research for creating new fungicides or herbicides, leveraging the bioactivity of the benzimidazole moiety.
• Material Science: Investigated as a monomer or additive for specialty polymers and advanced organic electronic materials due to its fused aromatic structure.
• Chemical Biology Probe: Employed in the design of molecular probes to study enzyme function and biological mechanisms in R&D settings.

Basic Information

Product Name	1-Cyclopentyl-5-Fluorobenzimidazole
CAS No.	1375069-26-3
Molecular Formula	C₁₂H₁₃FN₂
Molecular Weight	204.25 g/mol
Synonyms	5-Fluoro-1-cyclopentyl-1H-benzimidazole; 1-Cyclopentyl-5-fluoro-1H-benzimidazole; 1H-Benzimidazole, 5-fluoro-1-cyclopentyl-; 1375069-26-3; 5-Fluoro-1-cyclopentylbenzimidazole
EINECS	Contact for details

Quality Control

Our 1-Cyclopentyl-5-Fluorobenzimidazole is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.