Description

5-Bromo-2-Chloro-4-(Difluoromethyl)Pyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromo, chloro, and difluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for versatile palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig amination.
• Fluorine Chemistry: The difluoromethyl group provides a valuable handle for introducing fluorine atoms into target molecules, a common strategy in modern medicinal chemistry to modulate lipophilicity and metabolic profile.

Basic Information

Product Name	5-Bromo-2-Chloro-4-(Difluoromethyl)Pyridine
CAS No.	1374659-34-3
Molecular Formula	C7H5BrClF2N
Molecular Weight	264.48 g/mol
Synonyms	2-Chloro-5-bromo-4-(difluoromethyl)pyridine; 4-(Difluoromethyl)-5-bromo-2-chloropyridine; 5-Bromo-2-chloro-4-difluoromethylpyridine; 1374659-34-3; 2-Chloro-5-bromo-4-difluoromethylpyridine; Pyridine, 5-bromo-2-chloro-4-(difluoromethyl)-; 4-(Difluoromethyl)-2-chloro-5-bromopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Chloro-4-(Difluoromethyl)Pyridine is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical synthesis work. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.