Description

tert-Butyl 6-Cyano-2-Azaspiro[3.3]Heptane-2-Carboxylate is a high-value, protected spirocyclic amine building block of significant interest in modern pharmaceutical discovery. Its unique, rigid spiro[3.3]heptane scaffold and strategically placed nitrile and Boc-protected amine functional groups make it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by medicinal chemists and process R&D teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates targeting a range of therapeutic areas, including CNS disorders, oncology, and metabolic diseases.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its ability to modulate physicochemical properties and improve metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in the linker or warhead sections of bifunctional molecules designed for targeted protein degradation.
• Covalent Inhibitor Synthesis: The nitrile group can be utilized or further elaborated to create electrophilic warheads for the development of covalent kinase inhibitors and other targeted therapies.
• Peptidomimetic & Macrocycle Synthesis: The constrained spirocyclic structure is valuable for mimicking peptide turn conformations and constructing rigidified macrocyclic compounds with enhanced bioavailability.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and molecular probes for investigating biological pathways and target validation.

Basic Information

Product Name	tert-Butyl 6-Cyano-2-Azaspiro[3.3]Heptane-2-Carboxylate
CAS No.	1374658-94-2
Molecular Formula	C12H18N2O2
Molecular Weight	222.29 g/mol
Synonyms	2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-cyano-, 1,1-dimethylethyl ester; 6-Cyano-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester; tert-Butyl 6-cyano-2-azaspiro[3.3]heptane-2-carboxylate; Boc-6-CN-2-Azaspiro[3.3]heptane; 2-Boc-2,6-Diazaspiro[3.3]heptane-6-carbonitrile; 6-Cyano-2-N-Boc-2-azaspiro[3.3]heptane
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Cyano-2-Azaspiro[3.3]Heptane-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.