Description

3-Chloro-8-Nitroisoquinoline is a high-purity, synthetically valuable heterocyclic building block, identified by CAS NO 1374652-50-2. This compound is essential for advanced pharmaceutical research and fine chemical synthesis, offering a versatile scaffold for creating novel molecular entities. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other biological pathways where the isoquinoline core is active.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or pesticides, leveraging its nitro and chloro substituents for structural diversification.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in charge-transport layers.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to its reactive halogen and nitro groups.
• Dye & Pigment Industry: Acts as an intermediate for synthesizing specialized nitro- and chloro-substituted dyes and colorants.
• Academic & Contract Research: A valuable reagent for methodological studies and library synthesis in academic laboratories and CROs (Contract Research Organizations).

Basic Information

Product Name	3-Chloro-8-Nitroisoquinoline
CAS No.	1374652-50-2
Molecular Formula	C9H5ClN2O2
Molecular Weight	208.60 g/mol
Synonyms	8-Nitro-3-chloroisoquinoline; 3-Chloro-8-nitro-isoquinoline; Isoquinoline, 3-chloro-8-nitro-; 1374652-50-2
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-8-Nitroisoquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.