Description

6-Bromo-5-(Trifluoromethoxy)-1H-Indazole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of bromo and trifluoromethoxy substituents on the indazole scaffold, enabling precise molecular modifications and the introduction of key physicochemical properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the indazole core and fluorine atoms.
• Material Science: Serves as a building block for advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge transport materials.
• Chemical Biology Probe: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex molecular architectures.
• Fluorinated Compound Library Synthesis: Essential for constructing diverse screening libraries aimed at discovering compounds with improved metabolic stability and membrane permeability.

Basic Information

Product Name	6-Bromo-5-(Trifluoromethoxy)-1H-Indazole
CAS No.	1374651-78-1
Molecular Formula	C8H4BrF3N2O
Molecular Weight	281.03 g/mol
Synonyms	6-Bromo-5-(trifluoromethoxy)-1H-indazole; 5-Trifluoromethoxy-6-bromo-1H-indazole; 1H-Indazole, 6-bromo-5-(trifluoromethoxy)-; 6-Bromo-5-trifluoromethoxyindazole; 6-Bromo-5-(trifluoromethoxy)indazole; 1374651-78-1; 6-Bromo-5-(trifluoromethoxy)indazole
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-(Trifluoromethoxy)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.