Description

2,9-Diazaspiro[5.5]Undecan-1-One, 2-(1H-Indol-3-Ylmethyl)-9-(4-Methoxy-2-Pyrimidinyl)- is a complex, high-purity spirocyclic organic compound featuring both indole and pyrimidine pharmacophores. This advanced chemical intermediate is valued for its unique three-dimensional structure, which is critical for modulating biological activity and physicochemical properties in drug discovery. It is primarily utilized by pharmaceutical R&D organizations and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged scaffold.
• Kinase Inhibitor Synthesis: Employed in the synthesis of potential kinase inhibitors, leveraging the 4-methoxy-2-pyrimidinyl moiety.
• Preclinical Candidate Development: Integral to the synthesis of compounds for pharmacological profiling and in-vivo studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological pathways and target validation.

Basic Information

Product Name	2,9-Diazaspiro[5.5]Undecan-1-One, 2-(1H-Indol-3-Ylmethyl)-9-(4-Methoxy-2-Pyrimidinyl)-
CAS No.	1373765-19-5
Molecular Formula	C22H25N5O2
Molecular Weight	391.47 g/mol
Synonyms	2-(1H-Indol-3-ylmethyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one; 2-(Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one; 1373765-19-5; UNII-9K9F0E8Z7I; 9K9F0E8Z7I; CHEMBL3186660; AKOS025147324; BDBM50389385
EINECS	Contact for details

Quality Control

Our 2,9-Diazaspiro[5.5]Undecan-1-One derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support development projects with consistent quality and full traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C). Keep the container tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.