Description

Ethyl 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate Hydrochloride is a high-purity, synthetically derived chemical building block of significant importance in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex nitrogen-containing heterocycles, which are core scaffolds in numerous active pharmaceutical ingredients. This compound is essential for research and development chemists and process scale-up teams within the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for drug discovery and production.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel therapeutic agents, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and other conditions where the tetrahydroisoquinoline core is pharmacologically active.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic structure to create molecules with specific biological activity.
• Chemical Biology & Medicinal Chemistry: Employed as a versatile scaffold for constructing compound libraries used in high-throughput screening (HTS) to identify new drug candidates.
• Process Chemistry & Scale-Up: Supplied to contract development and manufacturing organizations (CDMOs) and in-house production facilities for the kilogram-to-ton scale synthesis of target molecules.
• Academic & Institutional Research: Utilized by universities and research institutes for methodological studies in organic synthesis and the exploration of new chemical reactions.
• Fine Chemical Synthesis: Acts as a building block for creating specialized dyes, pigments, and other performance chemicals that incorporate complex amine functionalities.

Basic Information

Product Name	Ethyl 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate Hydrochloride
CAS No.	1373223-04-1
Molecular Formula	C₁₂H₁₅Cl₂NO₂
Molecular Weight	276.16 g/mol
Synonyms	6-Chloro-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester hydrochloride; Ethyl 6-chloro-3,4-dihydro-1H-isoquinoline-1-carboxylate hydrochloride; 1-Carbethoxy-6-chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6-Chloro-1-ethoxycarbonyl-1,2,3,4-tetrahydroisoquinoline HCl; 6-Chloro-THIQ-1-COOEt HCl; 1373223-04-1; Ethyl 6-chloro-3,4-dihydroisoquinoline-1(2H)-carboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP and ISO 9001 principles to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.