Description

2H-Thiopyran, 3,6-Dihydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dioxide is a high-value organoboron building block, specifically a sulfone-containing cyclic boronic ester, with the CAS number 1370535-33-3. This compound is critical for modern synthetic chemistry, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by pharmaceutical R&D teams and advanced material scientists for constructing complex molecular architectures in drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing novel heterocyclic scaffolds in active pharmaceutical ingredient (API) development, particularly for central nervous system (CNS) and oncology targets.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient library synthesis for medicinal chemistry.
• Material Science Research: Used in the synthesis of organic electronic materials, such as novel polymers or small molecules for OLEDs and organic photovoltaics, where the sulfone group can modulate electronic properties.
• Agrochemical Synthesis: Employed in the research and development of new crop protection agents, leveraging its ability to introduce complex thiopyran motifs.
• Ligand and Catalyst Development: Acts as a precursor for creating specialized bidentate or tridentate ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules or activity-based probes for studying biological pathways and protein function.

Basic Information

Product Name	2H-Thiopyran, 3,6-Dihydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dioxide
CAS No.	1370535-33-3
Molecular Formula	C11H19BO4S
Molecular Weight	258.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-thiopyran 1,1-dioxide; 3,6-Dihydro-2H-thiopyran-4-boronic acid, 1,1-dioxide, pinacol ester; 4-(Pinacolatoboryl)-3,6-dihydro-2H-thiopyran 1,1-dioxide; 2H-Thiopyran-4-boronic acid, 3,6-dihydro-, 1,1-dioxide, pinacol ester; Thiopyran boronic ester sulfone; CAS 1370535-33-3; Sulfolene-derived pinacol boronate
EINECS	Contact for details

Quality Control

Our production of 2H-Thiopyran, 3,6-Dihydro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dioxide adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance with internal quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.