Description

Lotilaner is a potent and selective isoxazoline-class ectoparasiticide that targets the invertebrate GABA-gated chloride channels. Its high efficacy and favorable safety profile make it a critical active pharmaceutical ingredient (API) for veterinary and potential agricultural applications. This compound is essential for manufacturers developing next-generation parasiticidal formulations for companion animals and livestock.

Application

• Veterinary Pharmaceutical API: Primary use as the active ingredient in topical and oral parasiticides for dogs and cats.
• Companion Animal Health: Formulated into spot-on solutions, chewable tablets, and collars for the treatment and prevention of flea and tick infestations.
• Livestock Parasite Control: Investigated for use in controlled-release formulations for cattle, swine, and poultry against mites, lice, and ticks.
• Agricultural Pest Management: Research into its application for controlling specific agricultural pests, leveraging its unique mode of action.
• Pharmaceutical Intermediates: Serves as a key intermediate in the synthesis of more complex parasiticidal agents.
• Reference Standard: Used in analytical laboratories as a high-purity standard for quality control and regulatory testing of commercial products.

Basic Information

Product Name	Lotilaner
CAS No.	1369852-71-0
Molecular Formula	C₂₄H₂₃ClF₃N₃O₃
Molecular Weight	493.90 g/mol
Synonyms	N-[5-[3-Chloro-5-(trifluoromethyl)phenoxy]-2-methyl-3-(2,2,2-trifluoroethyl)phenyl]-2-methoxyacetamide; Credelio (Trade Name); ZA-36; A1443; Isoxazoline Insecticide; Ectoparasiticide; GABA Chloride Channel Blocker
EINECS	Contact for details

Quality Control

Our Lotilaner is manufactured under strict cGMP guidelines to ensure the highest standards of purity and consistency for pharmaceutical use. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, potency, and impurity profiles. We ensure compliance with relevant pharmacopoeial standards and can provide material suitable for use as a Pharmaceutical Reference Standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.