Description

2-Bromo-1-(tert-Butyl)-4-Chlorobenzene is a high-purity halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of halogen substituents and the sterically hindered tert-butyl group, which enables precise molecular construction and functionalization. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in constructing complex aromatic cores for small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its halogenated structure serves as a versatile handle for further chemical modification.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport molecules or monomers for specialty polymers.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development and quality control in chemical manufacturing.

Basic Information

Product Name	2-Bromo-1-(tert-Butyl)-4-Chlorobenzene
CAS No.	1369776-71-5
Molecular Formula	C10H12BrCl
Molecular Weight	247.56 g/mol
Synonyms	1-Bromo-2-(tert-butyl)-5-chlorobenzene; 2-(tert-Butyl)-5-chlorobromobenzene; 2-tert-Butyl-4-chlorobromobenzene; 4-Chloro-2-(1,1-dimethylethyl)bromobenzene; 5-Chloro-2-tert-butylbromobenzene; 2-Bromo-5-chloro-tert-butylbenzene; 1-tert-Butyl-2-bromo-4-chlorobenzene
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(tert-Butyl)-4-Chlorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to traceability and documentation supports cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.