Description

(1Rs,2Rs,5R)-Menthol-1,2,6,6-D4 is a deuterium-labeled isotopologue of the naturally occurring terpenoid, L-menthol. This high-purity stable isotope-labeled compound is critical for advanced analytical research, serving as an internal standard for precise quantification and metabolic pathway tracing. It is an essential material for pharmaceutical, flavor and fragrance, and academic research laboratories requiring the highest levels of accuracy and specificity in their analytical methods.

Application

• Internal Standard for Mass Spectrometry (MS): Used in GC-MS and LC-MS analyses for the accurate quantification of menthol and related compounds in complex matrices.
• Metabolic and Pharmacokinetic Studies: Enables the detailed tracing of absorption, distribution, metabolism, and excretion (ADME) pathways of menthol in biological systems.
• Pharmaceutical Research & Development: Supports drug development programs for products containing menthol, ensuring precise analytical validation and quality control.
• Flavor and Fragrance Analysis: Provides a definitive reference standard for authenticity testing, purity assessment, and compositional analysis of natural and synthetic menthol sources.
• Deuterium NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance studies for structural elucidation and dynamic analysis.
• Stable Isotope Labeling in Organic Synthesis: Serves as a building block for synthesizing more complex deuterated molecules for research purposes.

Basic Information

Product Name	(1Rs,2Rs,5R)-Menthol-1,2,6,6-D4
CAS No.	1369536-10-6
Molecular Formula	C₁₀H₁₆D₄O
Molecular Weight	158.29 g/mol
Synonyms	L-Menthol-1,2,6,6-d4; (-)-Menthol-1,2,6,6-d4; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol-1,2,6,6-d4; Deuterated L-Menthol; Menthol-d4; [1,2,6,6-²H₄]Menthol; 5-Methyl-2-(1-methylethyl)cyclohexanol-1,2,6,6-d4
EINECS	Contact for details

Quality Control

Every batch of (1Rs,2Rs,5R)-Menthol-1,2,6,6-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (by assay), isotopic enrichment, and other critical parameters to meet the stringent requirements of analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Assay)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.