Description

Isoquinoline, 4-Bromo-1-Chloro-6-Nitro- is a high-purity, multi-functional halogenated nitroisoquinoline derivative, serving as a critical advanced intermediate for complex organic synthesis. Its precise molecular architecture makes it an indispensable building block for researchers and manufacturers requiring specific substitution patterns on the isoquinoline core. This compound is primarily utilized in the development of novel pharmaceutical candidates, agrochemicals, and specialty materials where its unique bromo, chloro, and nitro functional groups enable targeted chemical transformations.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry research targeting kinase inhibitors, anticancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science: Building block for creating specialized organic ligands, dyes, and photoactive materials used in electronic and optical applications.
• Chemical Synthesis: Versatile intermediate for further functionalization, including cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution, due to the presence of reactive halogen and nitro groups.
• Academic & R&D: Essential reagent for universities and corporate R&D laboratories exploring novel heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	Isoquinoline, 4-Bromo-1-Chloro-6-Nitro-
CAS No.	1369199-81-4
Molecular Formula	C9H4BrClN2O2
Molecular Weight	287.50 g/mol
Synonyms	4-Bromo-1-chloro-6-nitroisoquinoline; 1-Chloro-4-bromo-6-nitroisoquinoline; 6-Nitro-4-bromo-1-chloroisoquinoline; 4-Bromo-1-chloro-6-nitro-isoquinoline; Isoquinoline, 1-chloro-4-bromo-6-nitro-; BRN 1369199-81-4
EINECS	Contact for details

Quality Control

Our Isoquinoline, 4-Bromo-1-Chloro-6-Nitro- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP principles and rigorous in-process controls guarantees a reliable supply of this high-value intermediate for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.