Description

8-Fluoro-3,4-Dihydro-2H-Isoquinolin-1-One is a high-purity fluorinated isoquinolinone derivative, serving as a critical building block in modern pharmaceutical and agrochemical research. Its value lies in its unique molecular scaffold, which is essential for developing novel bioactive compounds with enhanced properties. This advanced intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for improved metabolic stability and bioavailability.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study enzyme function and biological pathways.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced organic materials requiring fluorinated heterocyclic components.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Item	Details
Product Name	8-Fluoro-3,4-Dihydro-2H-Isoquinolin-1-One
CAS No.	1368930-77-1
Molecular Formula	C9H8FNO
Molecular Weight	165.17 g/mol
Synonyms	8-Fluoro-1,2,3,4-tetrahydroisoquinolin-1-one; 8-Fluoro-3,4-dihydro-1H-isoquinolin-1-one; 8-Fluoro-1,2,3,4-tetrahydroisoquinoline-1-one; 8-Fluoro-3,4-dihydroisoquinolin-1(2H)-one; 1368930-77-1; 8-Fluoro-1-oxo-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 8-Fluoro-3,4-Dihydro-2H-Isoquinolin-1-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with standards applicable for advanced pharmaceutical intermediates, supporting our clients' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.