Description

2-[(2,3-Dihydro-2-Oxo-1H-Indol-5-Yl)Methyl]-4-Thiazolecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound is valued for its role as a key synthetic building block in the development of novel therapeutic agents, particularly those targeting specific enzymatic pathways. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those with indole and thiazole pharmacophores.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new molecules with potential biological activity.
• API Development: Serves as a building block for the production of Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays and enzymatic studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2-[(2,3-Dihydro-2-Oxo-1H-Indol-5-Yl)Methyl]-4-Thiazolecarboxylic Acid
CAS No.	1368872-95-0
Molecular Formula	C13H10N2O3S
Molecular Weight	274.29 g/mol
Synonyms	5-[(4-Carboxy-1,3-thiazol-2-yl)methyl]-2-indolinone; 2-[(2-Oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazole-4-carboxylic acid; 2-(2-Oxo-2,3-dihydro-1H-indol-5-ylmethyl)thiazole-4-carboxylic acid; 2-(2-Oxoindolin-5-ylmethyl)thiazole-4-carboxylic acid; 4-Thiazolecarboxylic acid, 2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)methyl]-; CAS 1368872-95-0
EINECS	Contact for details

Quality Control

Our 2-[(2,3-Dihydro-2-Oxo-1H-Indol-5-Yl)Methyl]-4-Thiazolecarboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). Our quality assurance process includes rigorous identity confirmation, purity assessment, and impurity profiling using advanced analytical techniques to meet the exacting standards of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.