Description

8-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One is a high-purity, advanced pharmaceutical intermediate belonging to the isoquinolinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key synthetic building block in medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within the fields of oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, especially those targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and the generation of compound libraries for high-throughput screening.
• Organic Synthesis Building Block: Employed in the construction of more complex nitrogen-containing heterocycles due to its reactive bromine and carbonyl functional groups.
• Agrochemical Development: Potential application as an intermediate in the research and synthesis of novel crop protection agents and pesticides.
• Material Science Research: Investigated for the development of specialty chemicals and functional materials, such as organic semiconductors or ligands for catalysis.

Basic Information

Item	Details
Product Name	8-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1368622-07-4
Molecular Formula	C₁₀H₁₀BrNO
Molecular Weight	240.10 g/mol
Synonyms	8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-one; 8-Bromo-2-methyl-3,4-dihydro-1H-isoquinolin-1-one; 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinolinone; 1368622-07-4; 8-Bromo-2-methyl-3,4-dihydroisoquinolin-1(2H)-one; 8-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinoline-1-one
EINECS	Contact for details

Quality Control

Our 8-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this moisture-sensitive material from humidity. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.