Description

1-Chloro-8-Fluoroisoquinoline is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique halogenated isoquinoline structure, which enables precise molecular modifications in complex chemical pathways. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and anti-cancer research.
• Agrochemical Synthesis: Serves as a versatile building block for developing new pesticides and herbicides with enhanced efficacy.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.
• Fluorine Chemistry: The fluorine atom provides a metabolic stability handle, making it valuable for medicinal chemistry optimization programs.

Basic Information

Product Name	1-Chloro-8-Fluoroisoquinoline
CAS No.	1368531-41-2
Molecular Formula	C9H5ClFN
Molecular Weight	181.60 g/mol
Synonyms	8-Fluoro-1-chloroisoquinoline; 1-Chloro-8-fluoro-isoquinoline; Isoquinoline, 1-chloro-8-fluoro-; 1368531-41-2; 8-Fluoro-1-chloro-isoquinoline; 1-Chloro-8-fluoroisoquinoline; 1-Chloro-8-fluoro-2-azanaphthalene
EINECS	Contact for details

Quality Control

Our 1-Chloro-8-Fluoroisoquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.