Description

1-Bromo-8-Fluoroisoquinoline is a high-purity halogenated isoquinoline derivative, a crucial building block in advanced organic synthesis. Its value lies in its dual functionalization, offering versatile reactivity for constructing complex molecular architectures. This compound is primarily needed by pharmaceutical research and agrochemical development sectors for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly for kinase inhibitors and other biologically active molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorine and bromine substituents for enhanced activity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation.
• Ligand and Catalyst Development: Utilized to create novel chelating ligands for transition metal catalysts used in asymmetric synthesis.
• Fluorine Chemistry Studies: Acts as a model compound for investigating the electronic effects of fluorine substitution adjacent to nitrogen in heterocyclic systems.

Basic Information

Product Name	1-Bromo-8-Fluoroisoquinoline
CAS No.	1368512-30-4
Molecular Formula	C9H5BrFN
Molecular Weight	226.05 g/mol
Synonyms	8-Fluoro-1-bromoisoquinoline; 1-Bromo-8-fluoroisoquinoline; Isoquinoline, 1-bromo-8-fluoro-; 1368512-30-4; 8-Fluoro-1-bromo-isoquinoline; 1-Bromo-8-fluoro-isoquinoline; 8-Fluoro-1-bromoisoquinoline; 1-Bromo-8-fluoro-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Bromo-8-Fluoroisoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to guarantee traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.