Description

8-Chloro-3,4-Dihydroisoquinolin-1(2H)-One CAS NO 1368398-54-2 is a high-purity, synthetically valuable heterocyclic building block. This compound is a key intermediate in modern pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug candidates targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies to develop new bioactive molecules.
• Process Chemistry Development: Serves as a key starting material or intermediate in the scale-up and optimization of API manufacturing routes.
• Organic Synthesis: Employed in academic and industrial laboratories for constructing complex isoquinoline-based heterocycles.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	8-Chloro-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1368398-54-2
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	8-Chloro-1,2,3,4-tetrahydroisoquinolin-1-one; 8-Chloro-3,4-dihydro-1(2H)-isoquinolinone; 8-Chloro-1-oxo-1,2,3,4-tetrahydroisoquinoline; 8-Chloro-1,2,3,4-tetrahydroisoquinoline-1-one; 8-Chloro-1-isoquinolinone, 3,4-dihydro-; 1368398-54-2
EINECS	Contact for details

Quality Control

Our 8-Chloro-3,4-Dihydroisoquinolin-1(2H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.