Description

5-(But-1-Yn-1-Yl)-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate featuring a strategically functionalized indazole core. This compound is specifically engineered for use in sophisticated organic synthesis, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new therapeutic agents, particularly those targeting kinase inhibition or other enzyme-related pathways.
• Medicinal Chemistry Building Block: Used for structure-activity relationship (SAR) studies and lead optimization due to its reactive alkyne and protected heterocyclic functionalities.
• Agrochemical Research: Serves as a core structure in the synthesis of novel crop protection agents and pesticides.
• Chemical Biology Probe Development: Employed in the creation of molecular probes for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, multi-step organic transformations.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and new reaction methodology development.

Basic Information

Product Name	5-(But-1-Yn-1-Yl)-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole
CAS No.	1365889-00-4
Molecular Formula	C16H18N2O
Molecular Weight	254.33 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-5-(but-1-yn-1-yl)-1H-indazole; 5-But-1-yn-1-yl-1-(oxan-2-yl)indazole; 1H-Indazole, 5-(1-butyn-1-yl)-1-(tetrahydro-2H-pyran-2-yl)-; THP-Protected 5-Butynylindazole; 5-Butynyl-1-THP-indazole; 1365889-00-4; 5-(But-1-ynyl)-1-(tetrahydropyran-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 5-(But-1-Yn-1-Yl)-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for advanced intermediates intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.