Description

7-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring the isoquinolinone scaffold modified with a trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential therapeutic agents, particularly for central nervous system (CNS) targets, oncology, and anti-inflammatory applications.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Material Science: Investigated as a building block for specialty polymers and advanced organic materials that require specific electronic or fluorinated properties.
• Chemical Biology Probe Development: Employed in creating molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring complex fluorinated heterocycles.

Basic Information

Product Name	7-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1365759-12-1
Molecular Formula	C₁₀H₈F₃NO
Molecular Weight	215.17 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-1-one; 1(2H)-Isoquinolinone, 3,4-dihydro-7-(trifluoromethyl)-; 7-Trifluoromethyl-3,4-dihydro-1(2H)-isoquinolinone; 7-Trifluoromethyl-1,2,3,4-tetrahydroisoquinolin-1-one; 1365759-12-1; 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-1-one
EINECS	Contact for details

Quality Control

Our production of 7-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.