Description

6-Fluoro-1H-Indazole-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for modern organic synthesis. This compound matters as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. Pharmaceutical research organizations and fine chemical manufacturers need this material for constructing complex molecular architectures, leveraging its indazole core and carboxylic acid functionality for further derivatization.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science: Serves as a precursor for advanced organic materials, including ligands for catalysis and monomers for specialty polymers.
• Bioconjugation & Probe Development: The carboxylic acid group enables facile attachment to biomolecules or solid supports for creating diagnostic tools and chemical probes.
• Academic & Contract Research: Employed in medicinal chemistry programs and process development within university and CRO/CMO settings.

Basic Information

Product Name	6-Fluoro-1H-Indazole-5-Carboxylic Acid
CAS No.	1360943-00-5
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	6-Fluoro-1H-indazole-5-carboxylic acid; 6-Fluoro-5-carboxyindazole; 5-Carboxy-6-fluoroindazole; 6-Fluoroindazole-5-carboxylic acid; 1H-Indazole-5-carboxylic acid, 6-fluoro-; 1360943-00-5; 6-Fluoro-1H-indazol-5-yl carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1H-Indazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.