Description

Methyl 4-(Trifluoromethyl)Indole-3-Carboxylate is a high-value, fluorinated indole derivative that serves as a critical building block in advanced organic synthesis. This compound is prized for its ability to introduce both the indole scaffold and a metabolically stable trifluoromethyl group into target molecules, significantly influencing their physicochemical and pharmacological properties. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the indole core and the lipophilicity of the CF3 group.
• Material Science Precursor: Employed in the research of organic electronic materials, such as OLEDs and semiconductors, where fluorinated indoles can modify charge transport properties.
• Chemical Biology Probe: Serves as a scaffold for developing molecular probes and fluorescent tags to study biological processes.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Product Name	Methyl 4-(Trifluoromethyl)Indole-3-Carboxylate
CAS No.	1360892-32-5
Molecular Formula	C11H8F3NO2
Molecular Weight	243.18 g/mol
Synonyms	Methyl 4-(trifluoromethyl)-1H-indole-3-carboxylate; 4-(Trifluoromethyl)-1H-indole-3-carboxylic acid methyl ester; 1H-Indole-3-carboxylic acid, 4-(trifluoromethyl)-, methyl ester; Methyl 4-trifluoromethylindole-3-carboxylate; 3-Carbomethoxy-4-trifluoromethylindole
EINECS	Contact for details

Quality Control

Every batch of Methyl 4-(Trifluoromethyl)Indole-3-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (NMR, IR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.